Symbol
Name
ID

Ncf2
neutrophil cytosolic factor 2
MGI:97284

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Impaired oxidative burst

Granulomatosis

Lymphadenitis

Lymphadenopathy

Splenomegaly

Rectal abscess

Liver abscess

Eczematoid dermatitis

Recurrent bacterial skin infections

Discoid lupus rash

Osteomyelitis

Recurrent pneumonia

Absence of bactericidal oxidative respiratory burst in phagocytes

Anti-citrullinated protein antibody positivity

Rheumatoid factor positive

Immunodeficiency

Recurrent Burkholderia cepacia infections

Recurrent E. coli infections

Recurrent Klebsiella infections

Recurrent Serratia marcescens infections

Recurrent Staphylococcus aureus infections

Recurrent Aspergillus infections

Cellulitis

Disease(s) Associated with NCF2

autosomal recessive chronic granulomatous disease 2

rheumatoid arthritis

Mouse Phenotypes

increased germinal center B cell number

increased follicular B cell number

increased B cell number

increased KLRG1-positive NK cell number

decreased NK cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, alpha-beta memory T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased NK T cell number

decreased alpha-beta T cell number

decreased regulatory T cell number

decreased T cell number

increased T cell number

increased activated T cell number

decreased leukocyte cell number

abnormal spleen germinal center morphology

increased susceptibility to systemic lupus erythematosus

increased anti-double stranded DNA antibody level

lung inflammation

increased susceptibility to fungal infection

Availability

Mouse Genotype

Ncf2^{tm1a(EUCOMM)Wtsi}/Ncf2^{tm1a(EUCOMM)Wtsi}

Ncf2^{tm1b(EUCOMM)Wtsi}/Ncf2^{tm1b(EUCOMM)Wtsi}

Ncf2^{tm1b(EUCOMM)Wtsi}/Ncf2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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